Upregulation of DARS2 by HBV Promotes Hepatocarcinogenesis Through the miR-30e-5pMAPKNFAT5 Pathway
The osmoregulatory transcription factor nuclear factor of activated T-cells 5 (NFAT5) has been shown to play an important role in the development of many types of human cancers.
Efficacy of NVR 3-778, Alone and in Combination With Pegylated Interferon, vs Entecavir in uPASCID Mice With Humanized Livers and HBV Infection
NVR3-778 has high antiviral activity in mice with humanized livers and stable HBV infection, reducing levels of serum HBV DNA and HBV RNA.
Long-Term Outcome of Hepatitis B Virus-Related Chronic Hepatitis Under Protracted Nucleos(t)ide Analogues
Development of cirrhosis, events of liver decompensation and hepatocellular carcinoma (HCC) during the follow-up were the main endpoints, as the complication-free survival.
Why Do I Treat HBeAg-Positive Chronic Hepatitis B Patients with a Nucleoside Analogue
Sustained suppression of HBV replication is the cornerstone for preventing the progression of disease and prolonging survival in patients with CHB.
Chronic Hepatitis B
Suppression of HBV
Comprehensive Circular RNA Profiling Reveals the Regulatory Role of the CircRNA-100338miR-141-3p Pathway in Hepatitis B-Related Hepatocellular Carcinoma
Circular RNAs (circRNAs) represent a class of endogenous noncoding RNAs that have recently been recognized as important regulators of gene expression and pathological networks.
Efficacy and Safety of Tenofovir Disoproxil Fumarate in Preventing Vertical Transmission of Hepatitis B in Pegnancies with High Viral Load
The available evidence suggests that TDF is effective and safe in preventing vertical transmission of hepatitis B in pregnancies exhibiting a high viral load.
The Efficacy and Safety of Tenofovir in The Prevention of Hepatitis B Virus Recurrence Following Liver Transplantation
The results of this study, after a 36-month follow-up period, were encouraging and demonstrated that TDF therapy is safe and efficacious in treating HBV-positive organ transplant patients.
Significance of definitions of relapse after discontinuation of oral antivirals in HBeAg-negativechronic hepatitis B
The aim of this study was to assess the impact of different definitions on the rates of post-treatment relapse and therefore on the probability of retreatment in such patients who discontinued effective long-term NAs therapy.
The Definition of Relapse
Trajectories of serum hepatitis B surface antigen kinetics in patients with chronic hepatitis Breceiving long-term nucleos(t)ide analogue therapy
We investigated the patterns of serum HBsAg kinetics and their association with therapeutic outcomes in genotype B- or C-infected CHB patients receiving long-term NA therapy.
Chronic Hepatitis B
Serum HBsAg Levels
Predictors of Early Readmission in Patients With Cirrhosis After the Resolution of Bacterial Infections
CRP showed to be a strong predictor of early hospital readmission and 6-month mortality in patients with cirrhosis after hospitalization for bacterial and/or fungal infection.
Bacterial And/Or Fungal Infection
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